Van de Ven Brace Ends The Toffees' Run at New Home Ground
The Dutch defender emerged as the first backline player to score two goals in a English top-flight game for Tottenham since Jan Vertonghen in spring 2013.
Match summary
The Spurs defender heads into the net twice in opening period
Everton's defender has equalizer disallowed after video check
Senegalese midfielder scores final goal in 89th minute
This loss is Everton's initial at their new ground
The Tottenham defender scored on two occasions as Tottenham prolonged their winning streak in away games in the Premier League and delivered the Toffees their initial loss at Hill Dickinson Stadium.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the end of the previous campaign.
But Spurs captain the Dutchman struck twice from corners in the opening 45 minutes to place their strong form at jeopardy, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien thought he had levelled the scores five minutes after the defender's first goal, directing a bullet header past Guglielmo Vicario from an set-piece.
The Portuguese striker, in the meantime, missed a number of opportunities, while the Italian goalkeeper made a succession of excellent stops to ensure the London club went five matches on the road unbeaten in the Premier League.
But the VAR intervened, advising the match official to check the score on the pitchside monitor and the official ruled that the winger and the attacker were in an illegal position and had impeded with the Tottenham goalkeeper.
The win elevates the manager's side up to third in the Premier League, a handful of points off local foes and leaders the Gunners.
The Merseyside club stay 14th and are six points clear of the drop zone.
Spurs breakdown: The defender fulfils role at each end of pitch
After a drab midweek display in the Champions League against Monaco, where they managed a only two shots on goal, the manager opted for the French striker in attack instead of ex-Everton forward the Brazilian.
The summer signing was unable to make much of an impact before being substituted for Richarlison after 60 minutes on the pitch, but it emerged he wasn't needed in the final outcome.
Defender Van de Ven transformed into an attacking force to be feared.
Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur heading the ball back across the face of goal for an free Van de Ven to score.
And the captain - filling in as captain in the Argentine's unavailability - notched his second in added time as he rose above the England keeper to head home.
Van de Ven was equally impressive in defensive duties, partnering well with Kevin Danso as the duo dealt excellently with the numerous deliveries sent their way by the opposition.
Everton analysis: Toffees lacking striker's instinct
The club's new home had been a happy hunting ground, but it appears the freshness may have worn off slightly and fans flocked to the gates after Sarr's third for Spurs.
The end in Everton's unbeaten home run will not be a major worry for the manager, but their striker situation are.
Beto and the other striker - the Everton's two recognised strikers - had netted only one league goal between them before the weekend's match.
And they were failed to add to that poor record on a wet and gloomy evening on in Liverpool.
Beto's form was summed up when he opted to overhead kick a golden opportunity from near the goal, even with having room and time to readjust for a simpler shot that would have tested the keeper.
The substitute, as well, failed to influence the game after replacing the starter in the 65th minute.
It was not for a lack of chance. The majority of Everton's offensive moves came through the winger and the forward, who relentlessly whipped threatening balls into the Spurs box.
What next for these two sides?
The Toffees: Moyes' men head to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs travel to Newcastle's ground on late October for their fourth-round Carabao Cup match against Newcastle.